BENZODIAZEPINES AND CENTRAL GLYCINE RECEPTORS
نویسندگان
چکیده
منابع مشابه
Interaction of benzodiazepines with central nervous glycine receptors: possible mechanism of action.
Interaction of 21 benzodiazepines with the glycine receptor in the brainstem and spinal cord of rat have been evaluated in terms of their displacement of [(3)H]strychinine binding. The rank order of potency of the 21 drugs in displacing specific [(3)H]strychinine binding correlates (p < 0.005) with their rank order of potency in a vareity of pharmacological and behavioral tests in humans and an...
متن کاملGABA receptors and benzodiazepines.
From an historical standpoint, the development of our understanding of basic mechanisms of the actions of gamma aminobutyric acid (GABA) and benzodiazepines began on separate paths. Classical pharmacology revealed similarity between the actions of GABA and benzodiazepines in the central nervous system. Furthermore, pharmacological experiments with selective agonists and antagonists indicated th...
متن کاملBenzodiazepines Block 2-Containing Inhibitory Glycine Receptors in Embryonic Mouse Hippocampal Neurons
Thio, Liu Lin, Ananth Shanmugam, Keith Isenberg, and Kelvin Yamada. Benzodiazepines block 2-containing inhibitory glycine receptors in embryonic mouse hippocampal neurons. J Neurophysiol 90: 89–99, 2003. First published March 26, 2003; 10.1152/jn.00612.2002. Inhibitory glycine receptors (GlyRs) in the mammalian cortex probably contribute to brain development and to maintaining tonic inhibition....
متن کاملBenzodiazepines block alpha2-containing inhibitory glycine receptors in embryonic mouse hippocampal neurons.
Inhibitory glycine receptors (GlyRs) in the mammalian cortex probably contribute to brain development and to maintaining tonic inhibition. Given their presence throughout the cortex, their modulation likely has important physiological consequences. Although benzodiazepines potentiate gamma-aminobutyric acidA receptors (GABAARs), they may also modulate GlyRs because binding studies initially sug...
متن کاملComparison of typical and atypical benzodiazepines on the central and peripheral benzodiazepine receptors.
The affinities of typical and atypical benzodiazepines (BZs) for 3H-flunitrazepam (FLU) and 3H-Ro 5-4864, "peripheral" BZ, binding sites in the central nervous system (CNS) were compared. Each dissociation constant (Kd) value of the 3H-FLU binding sites in the cerebellum, cortex, hippocampus and spinal cord showed the similar results, although the binding maximum (Bmax) for the cortex and cereb...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1976
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1976.tb07643.x